Comment · Fri, May 20, 2016 · Ceretropic & Nootropics Depot
I have a questions about Examine.com and aniracetam.
Original post in this thread
Cynical_Dickhead69 · 2 points
On Examine.com on the section "Serum 3.2" it says in relation to "Plasma levels of aniracetam have been noted to peak at 2.3mcg/L (300mg) and 14.1mcg/L (1200mg) with an elimination half life of 35 minutes following ingestion of aniracetam.[1] It appears to have extensive first pass metabolism in the liver[1] with the main metabolites being N-anisoyl-GABA, 2-pyrrolidinone, and anisic acid. 95.8% of the dose is recovered, mostly in the urine, 28 hours post ingestion.[1]"
Does this mean that our body only uses 4.2% of the dose of aniracetam we use?
https://examine.com/supplements/aniracetam/
What they were answering
Cynical_Dickhead69 · 1 points
Ahhh ok thanks.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
No problem. It's a bit confusing if you are not familiar with it.
You'll probably find this tidbit interesting from the study Examine is referencing:
Only 0.2% of the parent drug reached the systemic circulation after administration of an oral dose due to marked first-pass hepatic metabolism. The plasma elimination half-life was 35 minutes.
So only .2% of Aniracetam actually reaches the blood stream, because the liver breaks it apart right away. Luckily N-anisoyl-GABA is active in itself. So you still get effects, even though you are not getting much free Aniracetam in the blood.
From the study:
The main metabolites of aniracetam are N-anisoyl-γ-aminobutyric acid (N-anisoyl-GABA), 2-pyrrolidinone and anisic acid. After oral and intravenous administration of [14C]-labelled aniracetam, approximately 84% of the dose was recovered in the urine, 0.8% in the faeces and 11% as carbon dioxide in expired air within 48 hours.
http://link.springer.com/article/10.2165/00002512-199404030-00007