Comment · Fri, May 20, 2016 · Ceretropic & Nootropics Depot
I have a questions about Examine.com and aniracetam.
Original post in this thread
Cynical_Dickhead69 · 2 points
On Examine.com on the section "Serum 3.2" it says in relation to "Plasma levels of aniracetam have been noted to peak at 2.3mcg/L (300mg) and 14.1mcg/L (1200mg) with an elimination half life of 35 minutes following ingestion of aniracetam.[1] It appears to have extensive first pass metabolism in the liver[1] with the main metabolites being N-anisoyl-GABA, 2-pyrrolidinone, and anisic acid. 95.8% of the dose is recovered, mostly in the urine, 28 hours post ingestion.[1]"
Does this mean that our body only uses 4.2% of the dose of aniracetam we use?
https://examine.com/supplements/aniracetam/
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
That means they recovered 95.8% of the dose as metabolites in urine. This means most of it is excreted as metabolites, and does not build up in the body. That is because Aniracetam's protein binding is low, and it is rapidly and extensively metabolized in the liver. So it does not accumulate in the body in any meaningful amounts like some compounds.