Comment · Sat, March 5, 2016 · Ceretropic & Nootropics Depot
Ageing: Restoration project (2016)
What they were answering
zalo · 2 points
So montelukast is an antiinflammatory... doesn't that mean the "rejuvenation" effects are temporary so long as the inflammation is suppressed?
I'll have to keep up my youthful blood transfusion regimen until science figures this out.
EDIT: another article on the subject: http://m.medicalxpress.com/news/2015-10-asthma-drug-rejuvenate-older-rat.html
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
It means that, in rats with age-related cognitive decline, blocking the actions of leukotrienes in the brain can improve cognition. It does not mean that it will improve memory in healthy people. This is not a new idea. Neuroinflammation being a cause of age-related cognitive issues has been a concept for a long time. The fact that it causes a complete reversal in disease-related cognitive decline in dementia is pretty cool, though. So yes, the "rejuvenation" effects are most likely only there as long as one is taking Montelukast, and the inflammation is suppressed. If you stop, and allow the inflammation to happen again, the cognitive decline will come back.
Side note: Montelukast is the only drug that completely eliminates the lung inflammation caused by my histamine disorder. I take it every time I go mountain biking or snowboarding. It's good to know that my brain is being protected from inflammation during that time too!