Comment · Tue, August 18, 2015 · Ceretropic

Making coluracetam nasal spray with PG/VG - not dissolving

Original post in this thread

warrentheape · 6 points

Hey, I'm trying to make a coluracetam nasal spray. 1 spray = 2,5mg, my dosage is 3x5mg so that fits. I put 250mg powder in 10ml 4:1 PG:VG solution, but it isn't dissolving. Do I need to heat this up? /u/MisterYouAreSoDumb ?

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Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Ceretropic

It's not going to work. First off, it's not going to be stable at room temperature. Second, there is no way a nasal spray will work with PG/VG as the solvent. It's just too thick. Not to mention the fact that coluracetam is not going to pass through the mucous membranes in your nose very well.

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Comment · Wed, August 19, 2015 · 1 pts
Yes, they are slightly different. The membranes in your mouth use saliva, and allow you to keep the compound in contact with them longer. Nasal does not allow you to keep the compound in contact with them as long. So a c

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