Comment · Thu, July 16, 2015 · Ceretropic
THT is back
What they were answering
DoreenGreen · 2 points
Sorry to go somewhat off topic, but I'd never heard of that compound, and looking it up gave me this:
We synthesized pharmacologic, behavioral, and biochemical approaches to examine the effects of 7, 8-DHF on spatial and fear memory functions, and morphological spine abnormalities in fragile X mental retardation 1 \(Fmr1\) gene knock-out mice. The study found that 4 weeks of treatment with 7, 8-DHF improved spatial and fear memory, and ameliorated morphological spine abnormalities including the number and elongation of spines in the hippocampus and amygdala
I've never heard of anything else that purports to have this effect - is 7, 8-DHF unique in this capacity thus far? If so it represents an extraordinarily promising (and novel) potential treatment for what some believe to be the pathogenesis of many of the negative symptoms of autism. Obviously lab-induced mouse FXS isn't a valid model for human autism, but it's still a result I've never seen elsewhere.
u/MisterYouAreSoDumb · Ceretropic
Yes, that does seem to be a pretty unique effect. I've seen other substances that are trying to target fragile X, but none that seemed to have ameliorated morphological spine abnormalities.
[Fragile X Syndrome and Targeted Treatment
Trials](https://mega.co.nz/#!FBARkQwA!eS3LwgOWJTYLbHBLM8Trpcc-IMFM4OaPBT_zSstiXIc)