Skip to content

Comment · Fri, June 19, 2015 · Ceretropic

[Review] MK-677 from Ceretropic, and some thoughts on insulin and GH.

Original post in this thread

aesthet · 2 points

I've been using the recommended 25mg/day dose of Mk-677 from Ceretropic for at least three weeks now. I haven't gotten relevant bloodwork for it yet (forgot to check the right boxes for it..)

But, the standard acute effects are present: flushing in the face, particularly my ears, and a strong hunger.

I will say that I've gained some weight since I've been on it, and that it's getting stored mostly in my legs, and calves. None on my upper body really, which is unique, because I am a male and males tend not to store fat there.

My caloric intake hasn't changed significantly, so I've been struggling to understand what is happening. I am lead to think that the unpredictable nature of the GH spikes caused by mk-677, as opposed to the predictable spikes caused by SubQ injections of GHRH/GHRP, are timing up with dietary intake, and are causing some level of insulin resistance.

It might be worth noting that in that often-discussed study regarding MK677 in the elderly over 7 months, they did show an increase in fat.

Contrastingly, with SubQ GHRP/GHRH, users are recommended to abstain from eating anything for a period of an hour before an…

What they were answering

TheLiberalSoup · 1 points

I see some people recommending to take those peptides before sleep and right after you wake up, or half an hour before each meal, or right before workouts. who's right?

u/MisterYouAreSoDumb · Ceretropic

You want to not eat an hour before, or 30 min after, dosing any of the GH peptides. Insulin response will blunt the GH release. If you are looking to lose weight, then the HGH-176-191 should be dosed just before a workout. That allows you to use the energy that is released from your fat stores. If you don't exercise right after taking it, you are not going to see any results. I usually dose right when I wake up, and wait a while to eat. Then I dose before an afternoon workout. I also dose before bed sometimes, as long as I have not eaten lose to the time of dosing.

So you always want to avoid food around the time of dosing, due to insulin affecting the efficacy of the GH release. That is for the GHRH and GHRPs. The HGH fragment should be taken just before a workout for best effects. Some people take the GH peptides 3-4x per day. So they could all be right, depending on what they are using, and what their goals are.

Other MYASD lines in this thread

Related in the archive

Postr/NootropicsMar 21, 2014

SEMAX Megadose

I am not one for the whole "megadosing" thing that a lot of people try. However, I am human, and I do make mistakes. That is what happened yesterday. I was reading through Russian studies on SEMAX, and got myself confuse

3592SemaxDosingPeptides
Commentr/NootropicsAug 15, 2013

Will heat or acidity degrade noopept? (can I put noopept in my morning cup of coffee?)

Noopept's melting point is 97*C (206*F). That is less than boiling, which is what most people use for coffee. So I would not suggest putting it in boiling water. I'd be worried about stomach enzymes too. Oral administra

17NoopeptDosingPeptides
Commentr/NootropicsFeb 25, 2016

Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments.

Full Study: [Brain-derived neurotrophic factor \(BDNF\) overexpression in the forebrain results in learning and memory impairments](https://mega.nz/#!4R53RbBK!L_Yy4H24mQ8TlhKA2nlCpOtTFLTv6nFXixyKlExblhw) >What may be th

15SemaxDosingPeptides
Commentr/NootropicsJan 22, 2014

Noopept in hot beverages?

Noopept's oral bioavalability is around 10% in comparison to IV administration. [Bioaccessibility of the new dipeptide nootropic drug noopept](https://mega.co.nz/#!sJZEmCzJ!Q5VNgBHRLbEDl9Tz6jSUDGgZrflox09TJivWIoa_CDg)

11NoopeptDosingPeptides
Commentr/NootropicsAug 29, 2013

Noopept- 1 Week Check-In

Replying to GetsEclectic · > First problem was, not taking it under the tongue, won't work at all unless you do. This is not true, noopept has high oral bioavailability. http://en.wikipedia.org/wiki/Noope

Noopept has low oral bioavailablity. Around 10% to be exact. Don't cite Wikipedia. I just changed the entry. Oral administration of noopept reaches much lower plasma concentrations than IV and sublingual. A lot of peopl

11NoopeptDosingPeptides
Commentr/NootropicsOct 27, 2017

[REQ] Epitalon update w/ results from telomere testing members.

Replying to eric1240 · Wow, that's crazy. I mean, I don't know how much the saliva test varies, but even if it was off by 10 years or so, going from the telomere length of an 80 year old to a 26 year old

For the first cycle, I ran 5mg/day for 20 days for Epitalon and Thymalin. I ran 10mg/day for GHK-Cu. I ran 1 gram a day L-carnosine. My second cycle I wanted to try a higher dose/lower time frame cycle. So I ran 10mg/d

8DosingPeptides