N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically (2014)

So this means that NAC is good for acute alcohol sessions. It will protect from the oxidative stress of a night out drinking. However, chronic use prevents mitochondrial regeneration of liver cells. That means chronic daily users of alcohol will not get protection from NAC, because it will not allow the liver to regenerate. Emoxypine might be a better substitute for NAC in chronic daily users of alcohol. I am still going to use it for the occasional night out drinking, since the cessation of the NAC the days/weeks following will give plenty of time for the liver to repair itself.