Comment · Tue, December 9, 2014 · Ceretropic
Non SERT-affecting NMDA atagonist
Original post in this thread
Bomb_Jack · 9 points
Hi all.
Ketamine is out of discussion because it's illegal. Analogues are unfindable at the moment (even S-ketamine seems very interesting).
Memantine is too expensive, especially considering you have to keep it dosing continuously (string antagonist just need a dose confined once in a while, depending how much the aftereffects last).
MXE and DXM, while theoretically good for the scope (have also very few studies on the back that confirm their equivalence to ketamine as rapid antidepressant), inhibit SERT and can cause serotonin syndrome in SSRI users. DXO which lacks SERT affinity, again, is unfindable.
And as it seems 3/4-meo-pcp are like mxe and dxm in this sense.
Could you point me out any available non-SERT binding NMDA antagonist ala ketamine?
What they were answering
Bomb_Jack · 1 points
Yes, DXO would be perfect or so, but I already mentioned it's not findable. If you know otherwise tell me please. It's obtainable from dxm but I don't have the mastering to do it without making a mess. (No jokes when it's a psychotropic chemical you have to consume)
I know the other one, but it's a different kind of antagonist, specific for some particular receptors whose mechanism are still under investigation. Also, too young to be found around.
u/MisterYouAreSoDumb · Ceretropic
I have thought about getting some DXO synthed. It would be a very useful NMDA antagonist, and not have the 5-HT interactions that DXM does.