Comment · Thu, November 13, 2014 · Ceretropic

What is Trkb down regulation and it's consequences?

Original post in this thread

[deleted] · 8 points

I read that this has been associated with Noopept but I can't make any sense of it. I'm not a scientist.

What they were answering

chrismd465 · 4 points

One strategy to possibly mitigate this would be forskolin use, which I believe /u/MisterYouAreSoDumb has suggested in the past. It's been reported to upregulate Trkb in mesenchymal stem cells.
http://www.ncbi.nlm.nih.gov/pubmed/23313493

However, the nuts and bolts of optimizing dosages to balance up and downregulation have yet to be worked out, as far as I am aware.

u/MisterYouAreSoDumb · Ceretropic

Yeah, I have use forskolin to try and up-regulate Trkb. However, I am not convinced that Semax or Noopept actually down-regulate it that much. We still need more data to know for sure.

Other MYASD lines in this thread

Comment · Tue, December 2, 2014 · 2 pts
Good find! I had not seen that study yet. [Semax, an analog of ACTH\(4–10\) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus](https://mega.co.nz/#!pdwHDTTb!NW_Sz2EQ42038G0gLKnNWtjGtSao0f

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