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Comment · Fri, June 20, 2014 · Ceretropic

The 'blood-brain barrier' vs. nootropics...why should they work?

Original post in this thread

bloodbrain1 · 1 points

I just read this article about the blood-brain barrier (BBB) in New Scientist and this phrase stood out: "The downside of this is that the BBB also completely blocks the vast majority of drugs. Exceptions include some classes of fat and lipid-soluble chemicals, but these aren't much help as such drugs penetrate every cell in the body – resulting in major side effects." How do we reconcile this with the observation that many nootropics and other drugs have effects on the brain?
http://www.newscientist.com/article/mg22229742.400-human-brains-ultimate-barrier-to-open-for-first-time.html#.U6HGt_ldXuQ?utm_source=NSNS&utm_medium=SOC&utm_campaign=twitter&cmpid=SOC%7CNSNS%7C2012-GLOBAL-twitter

What they were answering

killword-noot · 1 points

Is there evidence that direct transport from intranasal to brain/CNS exists in humans?

u/MisterYouAreSoDumb · Ceretropic

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

Intranasal delivery: An approach to bypass the blood brain barrier

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