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Comment · Thu, January 23, 2014 · Ceretropic

I'll be having GLYX-13 soon.. Solubility is low; any way to improve it?

Original post in this thread

odisa · 4 points

Title says most of it. Solubility is 2mg/ml water I found, however I can't imagine it being so low. I'll be administering s.c. injections; is there any way to improve solubility so I can lower the amount of injections to be administered?

I'm going to try to dissolve it at 10mg/ml in bacteriostatic water, though if that doesn't work, would it be such a bad idea to inject the resulting solution with its undissolved fine particles? I'd imagine this would be unadvisable for IV, but I'm talking subcutaneous, and I won't do it if the particles are chunky.

edit: Why the downvotes? Jealous? :O

What they were answering

earcaraxe · 1 points

http://www.prnewswire.com/news-releases/naurex-announces-initiation-of-phase-i-trial-for-second-generation-novel-antidepressant-agent-nrx-1074-210052381.html

This also sounds interesting. An orally available version of GLYX-13

u/MisterYouAreSoDumb · Ceretropic

Jason and I have been trying to figure out the structure for a while now. We have a few candidates that we might try at some point.

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