Comment · Tue, January 14, 2014
Another MDMA re-dose/redose question [first and second time MDMA experience inside]
Original post in this thread
YouKnowNothingJohn · 8 points
Although having read plenty of information on reddit and MDMA forums/sites, I still have a couple of questions regarding the dosing and specifically re-dosing of MDMA. I am familiar with the reasons behind the advise to only re-dose once shortly into your roll. Let me first give you some background.
Warning, long post, skip to bottom if not interested
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##Background
Our group uses MDMA at home and on festivals, the usage is quite low since we strictly keep three or more months between each use. No crazy amounts of MDMA are taken either. Living in the country we live in, we fortunately have access to high quality xtc pills and government testing facilities. At the moment we have some 100% clean pills with 205mg of pure MDMA inside.
For me personally I have used MDMA two times, both at festivals, and we will do a home session within one month's time. The last time we used I had already purchased some vitamin C and magnesium supplements to try to make the roll a bit safer.
Everyone in the group was into the idea of doing MDMA as safe as we could. I started reading a lot on how MDMA works and made my own supplement list based on different sources but mainly posts by Miste…
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb
My supplementation is not going to do anything for down-regulation, or desensitization. It's merely there to protect you from the harmful effects of the reactive species that get created, and to slow the process creating them. Don't go chasing the feeling. The more times you re-dose, the greater the risk of damage. There is only so much the antioxidants can do. Pair that with the nutrient deprivation that is inevitable during the usual partying sessions, and your body is not going to be happy with you after a while.
That being said, it sounds like the two experiences differ in absorption. Did you have an empty stomach the first time, but the second time you had eaten before taking the MDMA? Did you alter the time in between taking the grapefruit juice/vitamin C and the Tums? An acidic stomach is going to make absorption very slow.
Also, I have found out that there are various things that will drastically alter the MDMA experience. SAMe is one of those. It makes the come-up very long and drawn out. I have not figured out the reason for this yet. Also, I know that MDMA is supposedly not transported by P-glycoprotein. However, I have a feeling that it does affect serum levels in some way. So inhibitors of P-glycoprotein might affect the come-up as well. Piperine, in black pepper, is one of those things.
So was your diet or timing different between the two experiences?