Comment · Thu, January 9, 2014 · Ceretropic

Effects of antidepressant drugs on synaptic protein levels and dendritic outgrowth in hippocampal neuronal cultures

What they were answering

Harvster · 2 points

Anyone care to translate for the less science-y people?

u/MisterYouAreSoDumb · Ceretropic

Antidepressants of differing types prevented hippocampal damage caused by nutrient deprivation. They did this by increasing the levels of BDNF (brain derived neurotrophic factor), encouraging outgrowth of the neuronal dendrites.

Essentially, various antidepressants lead to increased levels of BDNF in the hippocampus, which is what the brain uses to repair and grow its connections. They do this by modulating the CaMKII, KN-93, PKA, H-89, and PI3K complexes/pathways.

Other MYASD lines in this thread

Comment · Thu, January 9, 2014 · 3 pts
Because they work on different sub-systems and pathways that lead to the BDNF increase. This study showed that tianeptine relied on phosphatidylinositide 3-kinase enzymes to increase BDNF levels, while the others did not

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