Comment · Thu, October 31, 2013 · Ceretropic
Have yet to find definitive answer on Nootropics and amphetamines.
Original post in this thread
tandoshi · 2 points
I have looked through the nootropics, stackadvice and adhd subreddits, and yet have not found a definitive answer on whether nootropics can be taken with amphetamines. I recently started 10mg of vyvance after several years on strattera and wellbutrin.
The answers seem to go back and forth:
Dont take both
http://www.addforums.com/forums/showthread.php?t=66514
http://www.longecity.org/forum/topic/42083-repairing-cognition-after-vyvansepiracetam-excitotoxicity/
http://www.longecity.org/forum/topic/50056-piracetam-and-vyvanse-lisdexamfetamine-questions-and-discussion/
No Issues when taking both/Its fine to take both
http://www.reddit.com/r/StackAdvice/comments/1o270z/i_dont_feel_like_anything_really_helps_me_any/\
http://www.reddit.com/r/StackAdvice/comments/1iqtoj/any_stack_advice_or_suggestions_welcome/
http://www.reddit.com/r/StackAdvice/comments/1cmyqh/what_should_i_addsubtract_from_my_beginners_stack/
http://www.longecity.org/forum/topic/58760-amphetamine-adhd-stack-question/
Ciltep stack is much better to take with a stimulant
http://www.whatarenootropics.com/regimens/chemically-induced-ltp-ciltep-regimen/
http://www.reddit.com/r/Nootropics/comments/y26dv/ciltep…
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
I will copy what I wrote a while ago:
There is no evidence that piracetam or other racetams exacerbate excitotoxicity at either the NMDA or AMPA receptor sites. In fact, there is evidence that racetams not only increase the influx of calcium and potassium though the various ion channels to enhance transmission, but also close the channel to protect from too high of concentrations as well.
http://www.ncbi.nlm.nih.gov/pubmed/9195198
The results suggest that piracetam and GVS-111 suppression of voltage-activated calcium and potassium currents of the neuronal membrane may regulate (both up and down) Ca2+ influx into neurons.
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http://ebm.rsmjournals.com/content/early/2012/10/05/ebm.2012.012128
We found that piracetam inhibited native CaV2.2 channels in superior cervical ganglion neurons in a dose-dependent manner
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http://www.sciencedirect.com/science/article/pii/S1059131197800222
This one found that piracetam protected from a known calcium and sodium channel convulsant.
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https://asm.confex.com/ipa/2003_Geneva/techprogram/paper_2223.htm
Our results allow to suggest that a desirable profile of action of nootropics should include a selective suppression of slow-inactivatng potassium currents without affecting (or with augmentation of) the fast-inactivating A-current.
So I cannot find any evidence of any racetam exacerbating excitotoxitiy at either the AMPA or NMDA sites. However, there are studies showing that they modulate both the influx and blockage of Ca2+ and K+ through their respective ion channels. They also increase membrane fluidity, which provides other neuroprotective benefits aside from their effects at the ion channels. All evidence points to them being perfectly safe and neuroprotective.