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Comment · Sun, October 13, 2013

Why Do Certain Drugs Cause Bruxism?

What they were answering

ADrugUser · 2 points

With MDMA though, alpha(2)-adrenoceptor agonism may be a contributing factor too: http://www.ncbi.nlm.nih.gov/pubmed/15056109

u/MisterYouAreSoDumb

True. However, the alpha(2)-adrenoceptors are G protein receptors that indirectly lead to an increase in calcium transmission through ion channels. The actual end result mechanism is what I was talking about. This is why magnesium supplementation helps mitigate the bruxism from MDMA.

One could attack the issue from the other side too. Although I am not sure what other downstream effects would happen from blockage of the alpha(2)-adrenoceptors.

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