Comment · Wed, September 18, 2013
Amphetamines Tolerance
Original post in this thread
[deleted] · 7 points
I've built up somewhat of a tolerance to amphetamines. It's too expensive to continue.
Amphetamine tolerances are always described as pretty long term, but that's usually in cases of sustained use for years.
I've been using amphetamines for less than a year, not regularly, and only started heavily using them 3 or 4 months ago.
Is my tolerance going to lower at a faster rate than someone who needs the same amount for a similar high but has been taking them daily for years? I use, at this point, 2-3 times a week, and a satisfying high (well, as satisfying as it can get) would require 100+mg's adderall for an afternoon.
I eat probably 65-75% and snort 25-35% of the time if that's important.
What they were answering
its4thecatlol · 1 points
DXM and memantine are effective at preventing tolerance. I've never read of them being able to lower it. It's an important distinction.
u/MisterYouAreSoDumb
Low level tolerance can be reversed. High tolerance seems to be a lot more stubborn. However, the mechanism is the interesting part. If we can figure out what sub-mechanism of the NMDA receptor is causing it, we might be able to find a better substance.