Comment · Fri, August 23, 2013 · Ceretropic
"...methylene blue's hormetic dose–response in normal rodents is behaviorally effective within 1–4 mg/kg and becomes ineffective by 10 mg/kg"
Original post in this thread
NellucEcon · 4 points
This paper states that the optimal dose of methylene blue is between one to four mg/kg to improve memory processes and protect neurons from oxidative stress in rats. If the optimal per kilogram dose is the same for humans as for rats, then a 75 kg human should take a 150mg dose of methylene blue. However, many in the /r/nootropics community seem to think that 60 mcg to 5 mg is the optimal daily dose for humans. What accounts for this discrepancy?
It is worth noting that a recent (apparently successful) alzheimers clinical trial used 50-100 mg.
What they were answering
NellucEcon · 2 points
So, why do many redditors seem to recommend the 60 mcg dose?
u/MisterYouAreSoDumb · Ceretropic
Many people on Longecity have tried all sorts of doses. 60mcg is what everyone seems to react to best.
http://www.longecity.org/forum/topic/51982-methylene-blue-dosing-and-products/