Comment · Tue, June 11, 2013
Scientific sources for MDMA 1-3 month rule
Original post in this thread
CageFury · 12 points
I have seen people on this sub saying you should leave a gap of 1-3 months between taking MDMA. I have yet to see a credible scientific source for this rule. Can somebody post a credible scientific article to show me where this rule comes from?
Thanks
What they were answering
CageFury · 2 points
binding sites for [125I]MIL was back to control levels
So the logic is that taking any substance before a binding site is back to control levels is bad and any substance taken immediate after the binding site is back to control levels is fine; or is there something about the binding site for [125I]MIL?
u/MisterYouAreSoDumb
Taking MDMA again before your 5-HT receptors have up-regulated back to normal levels, will cause them to down-regulate at an even faster rate. This is will just cause your tolerance to shoot up. Pair that with the fact that people want the same effects they had before, so they just up their dose to compensate, and you have extremely rapid tolerance buildup. Not to mention the fact that the higher doses are causing more damage.
The reason I wait 3 months between uses is not so much damage, but tolerance. You can protect yourself from 5-HT system damage, while still increasing your tolerance to MDMA. Since MDMA's tolerance is not fully understood, and is very hard to reverse, keeping that rule in place ensures you don't "lose the magic." Again, these are merely estimates based on lot of scientific and anecdotal evidence.