Comment · Tue, April 2, 2013 · Ceretropic
Has anyone tried N-acetylcysteine or N-Acetylcysteine amide?
Original post in this thread
ontodynamics · 19 points
http://www.ncbi.nlm.nih.gov/pubmed/23538074
N-Acetylcysteine (NAC) is a precursor to the essential amino acid, cysteine. Unlike cysteine, NAC can penetrate the blood-brain barrier such that by oral supplementation, it can increase blood and brain levels of cysteine. Preclinical data, case reports, and clinical studies indicate potential benefits of NAC for the treatment of addictions, bipolar depression, schizophrenia, autism, obsessive-compulsive disorder (OCD), tri-chotillomania, nail biting, skin picking, overdoses, and environmental toxic exposures.
NAC plays important roles in metabolic pathways believed to contribute to psychi-atric disorders:
1. By increasing levels of brain cysteine, NAC was able to modulate glutamatergic and dopaminergic pathways. In vitro studies show a reduction in synaptic release of glutamate and an increase in dopamine release.
2. Oxidative stress has been implicated as contributing to psychiatric disorders.
Glutathione (GSH) is the body’s main endogenous antioxidant. As a precursor to GSH, NAC has been widely used to replenish GSH, for example in the treatment of acetaminophen overdose. In addition, NAC directly scavenges reactive ox…
What they were answering
El-Chapo · 2 points
Just out of curiosity, how is the rest of your diet in terms of combating hang overs? I'm really interested in trying this out (getting married in a couple months need to be lucid but want to have an awesome time) and so I'm looking for a bit more of an explanation. I've found that a really healthy diet (vague, I know, but basically no processed food and lots of great shit) helps somewhat with hang overs but all "cures" just end up being placebo like or gimmicky. Anyway, I'm seriously interested in anything else you have to offer if it's convenient for you to do so!
Thanks
u/MisterYouAreSoDumb · Ceretropic
A good magnesium supplement, like magnesium glycinate, is a must. Also a good B complex. I have a few coconut waters for during and after drinking to maintain electrolyte levels and hydration. My diet is fairly healthy. I eat mostly Thai food, sushi, and various vegan meals.