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Comment · Fri, March 22, 2013 · Ceretropic

Vyvanse (lisdextafetamine) + modafinil combination - what will happen?

Original post in this thread

dotamakesmesad · 14 points

I've done some reading on this combination but haven't found anything scientific enough to be willing to give it a try. Does anyone know what the interaction is?

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · Ceretropic

As far as interactions from the CYP450 enzyme induction by modafinil is concerned, it should not affect the metabolism of lisdexamfetamine. It appears that it's metabolism is not meditated by any of the CYP450 enzymes.

http://dmd.aspetjournals.org/content/35/1/180.short

As for the CNS effects, I am not sure the interactions. I assume dextroamphetamine is going to have a higher binding affinity than modafinil for all transporters. They might potentiate each other, but I am not sure.

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