Comment · Thu, March 21, 2013
Prozac after MDMA?
Original post in this thread
[deleted] · 7 points
After talking to a friend of mine, I'm interested in a combination of things going into a roll in the next few weeks. My friends says I should take 1200mg piracetam for 4 days before and the day of my roll, and for 4 days after.
He also says that I should pre/post load with 5htp, which I already do.
The only thing he says that scares me-he wants to give me a prozac to take 3-6 hours after I roll which he says will decrease the chance of neurotoxicity and prevents too much dopamine being released and reabsorbed. From everything I've read in this sub, SSRI's and MDMA do not combine. But would that actually make sense for after a roll?
Also, thoughts on the piracetam supplement? How much would it affect the roll? What would be a dose for a light/medium/heavy roll if I take piracetam beforehand since it potentiates MDMA?
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb
Fluoxetine has been proven to proven neurotoxicity when given up to 5 hours after an MDMA dose. It does this by blocking the SERT and not allowing the hydroxyl radicals to enter the neurons. It also is a CYP3A4 inhibitor, which prevents MDMA from N-demethylating to MDA. Don't wait 6 hours, as 5 hours was the max cutoff in the studies.
If you have not lost the magic, then piracetam is not needed. I do not like the feeling of racetams on MDMA. It kills the empathy. I always take it the week after, though. Also, don't preload with 5-HTP. If your 5-HT stores are fine, then there is not need. You could actually cause some down-regulation if you preload. Postloading is good. Always take 5-HTP with EGCG, or you are wasting it and possibly causing heart valve damage.
http://www.reddit.com/r/DrugNerds/comments/15m9sf/mdma_supplementation/