Comment · Wed, March 20, 2013 · Ceretropic

What makes Kava different than other GABA agonists?

Original post in this thread

[deleted] · 6 points

From what I understand, Kava is non addictive and does not cause from tolerance, which seems to be the case with other GABA agonists.

Not sure if I'm missing something, but things like benzos, phenibut etc... all seem to have this issue, why not Kava?

Thanks

What they were answering

[deleted] · 3 points

I'm not 100% sure, but a quick google seems to suggest so:

In addition, kava-lactones bind to GABA-receptors in the brain - docking sites for the natural chemical GABA, responsible for feelings of wellbeing and euphoria. By binding to these sites, kava-lactones stop GABA being broken down chemically and flushed away, sustaining the feelgood factor longer than a stimulant such as alcohol.

u/MisterYouAreSoDumb · Ceretropic

It does not agonize the GABA receptors directly.

http://www.ncbi.nlm.nih.gov/pubmed/12845414

Kava extracts produce significant murine anxiolytic-like behavioral changes and sedation that are not mediated through the benzodiazepine binding site on the GABA(A) receptor complex.

Other MYASD lines in this thread

Comment · Wed, March 20, 2013 · 1 pts
Did you read through the discussions we had on this post? http://www.reddit.com/r/Nootropics/comments/18k4fg/enhanced_cognitive_performance_and_cheerful_mood/

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