Comment · Fri, December 7, 2012
Ketamine, grapefruit juice and your bladder.
Original post in this thread
Cannibalsnail · 10 points
I'm not 100% on this, but the science looks OK so far. Feel free to correct me.
Ketamine is metabolized in the liver predominantly by an enzyme group called CYP3A4. This is responsible for degrading it into Norketamine which has no real psychoactive value and is believed to be responsible for the bladder damage associated with its usage.
Grapefruit juice is a potent inhibitor of CYP3A4 and hence drinking a glass or 2 around half an hour before administration of Ketamine should reduce its metabolization, with an unknown effect on potency, hence decreasing bladder damage.
WARNING: THIS WILL NOT REDUCE IT 100% AND REGULAR USE OF KETAMINE WILL STILL CAUSE SERIOUS DAMAGE TO NUMEROUS BODILY SYSTEMS.
What they were answering
deepfunk · -1 points
Vitamic C kills MDMA. hence the Buzzkill.
u/MisterYouAreSoDumb
What are you talking about? Abscorbic acid does not kill MDMA! The only way it could affect your roll is if your stomach gets too acidic, it will prevent full absorption through your GI tract. That is why if you are drinking grapefruit juice and vitamin C, you take Tums to equal it out. ALWAYS take vitamin C with your MDMA, as it will prevent hepatic toxicity due to MDMA's metabolite HHMA.