Comment · Fri, December 7, 2012
Ketamine, grapefruit juice and your bladder.
Original post in this thread
Cannibalsnail · 10 points
I'm not 100% on this, but the science looks OK so far. Feel free to correct me.
Ketamine is metabolized in the liver predominantly by an enzyme group called CYP3A4. This is responsible for degrading it into Norketamine which has no real psychoactive value and is believed to be responsible for the bladder damage associated with its usage.
Grapefruit juice is a potent inhibitor of CYP3A4 and hence drinking a glass or 2 around half an hour before administration of Ketamine should reduce its metabolization, with an unknown effect on potency, hence decreasing bladder damage.
WARNING: THIS WILL NOT REDUCE IT 100% AND REGULAR USE OF KETAMINE WILL STILL CAUSE SERIOUS DAMAGE TO NUMEROUS BODILY SYSTEMS.
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb
http://etheses.whiterose.ac.uk/2104/1/Khurram_Shahzad_MSc_Thesis.pdf
>The main findings were that;
Ketamine and nor-ketamine were equally toxic to NHU cells in a
concentration dependent manner.