Archive

Fadogia vindicated?! https://pubmed.ncbi.nlm.nih.gov/35969364/

Replying to RarageInTheGarage · I wonder if NSI-189 would have passed under the old MARDS. It really sucks how that failed and didn't make it to market; there's nothing else out there quite like it. I do think NS…

Well NSI-189 was assessed using both the MARDS and HAM-D-17 scales, and failed to reach clinical significance. However, it did reach clinical significance in the CPFQ (Cognitive and Physical Functioning Questionnaire) and the Symptoms of Depression Questionnaire (SDQ), along with…

N. DEPOP NEEDS to look into things that work on EAAT2 glutamate pump expression in central nervous system, therefore reducing glutamate toxicity.

Replying to chutney1 · Interesting, digging into IEG expression now. Thank you for the pointer there, not sure I would have stumbled upon this otherwise. Are there any stacks you would recommend to som…

I don't really have a proven answer, unfortunately. We are still learning about IEG expression. Perhaps this EAAT2 targeting will prove to be a workable strategy. We are certainly missing some big piece of the picture with long-term tolerance, based on reports from many people ov…

Lion's Mane Mushroom (1:1 extract) or 7,8-Dihydroxyflavone

Replying to killberos · I been on your Lions mane 8:1 extract since last year. While cycling NSI several times since then. I think I was looking for an NSI like effect instead of evaluating it for itself.

Yeah, it's not going to have the same acute effects as NSI-189. However, our new 4-DMA-7,8-DHF is much stronger and has more acute effects. That might be one you are looking for. It should be up soon.

Replicating LSD microdose

Replying to xyz679 · Actually there was one drug Pfizer was developing a couple years back, some human growth factor or something, it was meant to treat cachexia so it stops cells around the body from …

Hmmm, sub-Q injection that made you look younger. That looks like it was PF-06946860. https://clinicaltrials.gov/ct2/show/NCT03599063 They went from 0.1mg to 100mg. I wonder what dose you got? LOL. No idea what the compound is or its mechanism. They say "Growth Factor Blocker" on…

NSI-189 Temperature Degradation?

Replying to DionysianSoul · I spent ages finding the degradation temps for all my shit, only thing I have that might have lost a decent amount of potency is T3. No idea where you got the NSI figure but I’m no…

We were one of the first in the world to sell NSI-189 back on Ceretropic. So we did all the lab analysis, including melting point, in our lab. T3 is one that is less stable, that's true.

NSI-189 Temperature Degradation?

Replying to DionysianSoul · In that case would I need to throw away the Minocycline too? Also, I’m not sure if it was 50*C, it was just my bedroom with an electric heater and borderline sauna-like. I’m a bit …

Minocycline has a high melting point, too. It's likely fine.

NSI-189 Temperature Degradation?

Replying to DionysianSoul · Last comment sorry, but is it worth reordering another massive stock or is it almost definitely fine - felt like it was very easily above 50*C, I couldn’t stand being in the room f…

50*C is hot, but not hot in chemistry terms. It's probably just fine.

NSI-189 Temperature Degradation?

Replying to DionysianSoul · It’s freebase but guessing it’s not a huge diff, the Minocycline is gonna have to be binned though...

Freebase will have a lower thermal decomp temp than the phosphate, but not enough to make a difference in this instance.

NSI-189 Temperature Degradation?

Replying to DionysianSoul · Appreciate it, no idea how you know all of this shit but if anyone does it’s you - thanks 🙏 (Really was like a sauna tho)

Thermal degradation temps would be over 200*C. So I would hope your room was not that! LOL

NSI-189 Temperature Degradation?

Replying to DionysianSoul · Paging u/misteryouaresodumb (It’s in the science.bio plastic jars, inside a baggie). The room was incredibly hot though, unbearable to be in there for too long. Max 24 hours.

The thermal degradation temps for NSI-189 are so high, you would never be able to feasibly reach them in a room like that.

Kanna (zembrin) / Saffron

Replying to RSGC9 · 1) Good to know, thanks for keeping us updated. I've tried so many things let me list down what I remember, racetams, adaptogens, Agmatine, ppap, selegiline, modafinil, nsi-189, t…

You could use theacrine instead of caffeine to help with tolerance. Also, extended release caffeine might help prevent the pikes and dips that can make tolerance worse. Have you tried our DynaMAX yet? Also, cordyceps and panax ginseng are good to either replace caffeine, or allow…

Neuralstem stock now worth ~1/100 of that before announcing NSI-189 MDD efficiency 'failure'

Replying to ebowden · Ah, right, couldn't hope for even the piecemeal IP to be THAT cheap despite the crash. As far as new products that fit with the new "natural extract" direction you are going in, ha…

No, actually! I will have to read up on it.

Neuralstem stock now worth ~1/100 of that before announcing NSI-189 MDD efficiency 'failure'

Replying to amemento · You're right, it's a pity that such a promising drug like NSI-189 with scientific evidence of it working and a whole lot of andecdotal one, will be just lost due to incompetence on…

They will probably sell off their IP individually once they finally admit Neuralstem's days are over and nobody is coming to buy them outright. I would imagine some company would buy the patent to NSI-189 if the price was right, and develop it for a more limited purpose.

Neuralstem stock now worth ~1/100 of that before announcing NSI-189 MDD efficiency 'failure'

Replying to ebowden · Would you consider buying them when they went really low just to be able to use such a promising compound? Do you think this development might allow vendors like what Ceretropic wa…

I am far from a larger pharma company with the resources to pick up where they failed. There would be no point in buying their IP without the ability to do something profitable with it. They will likely just die off and sell their IP piecemeal.

Neuralstem stock now worth ~1/100 of that before announcing NSI-189 MDD efficiency 'failure'

Replying to ranza · Thank you, this what I’ve been expecting to hear. Do you know whether they can/will release the full trial results?

I highly doubt it. They are out of money and bleeding cash. Their only hope is to sell to a larger pharma company, but none seem interested. Honestly, there seemed to be some manipulation/insider trading going on as well. Not that the SEC has the resources to go after people righ…

Neuralstem stock now worth ~1/100 of that before announcing NSI-189 MDD efficiency 'failure'

Neuralstem are a bunch of amateurs regarding business and public relations. They could have spun those results in a positive manner, as they did show significance in their secondary endpoints. However, they were too dumb to do that. So all anyone talked about was not meeting the…

7,8-Dihydroxyflavone in ND

Replying to voyager256 · OK I understand, but probably not every company will be as eager to chase all vendors as NeurlalStem did with their NSI-189. Anyway I hope you will be successful in finding natural…

Yeah, some companies are not going to police their patents as much as Neuralstem did. However, I am not going to take that chance. We are too large to fly under radars now. We have to abide by the rules. There is too much at stake. >BTW: Have you also abandoned efforts to synthes…

Significant depression/anxiety from 7,8-dihydroxyflavone. High BDNF thoughts?

Replying to lord_abbott · Any chance of NRX1074, matey? TeamTLR claim to have it but you know them. The GLYX-13/NRX1074 drugs are very promising stuff for those of us with resistant Anhedonia.

Probably not. That's going to be another one like NSI-189, where the patent holder defends it pretty heavily. There are also no reference standards. So developing methods will be pretty costly.

Neuralstem Presents Positive Updated Data from Phase 2 Study of NSI-189 in Major Depressive Disorder

Replying to Majalisk · Ah, that’s why I just saw that they jumped 75%

I almost thought I was looking at the wrong stock when I woke up and looked at my watch list. I never bought back in after selling at $6, though. I thought for sure they were heading toward delisting. Their executive team has no idea how to manage investor sentiment. I knew NSI-1…

Neuralstem (CUR) Halted on LUDP After Announcing Phase 2 NSI-189 Data Now Expected Ahead of Schedule.

Replying to yeahisaid · The stock has a lot of volatility. I also bought in the past few days as well. In 2014 the price was >$50. Do you have any idea why it tanked? Did they fail a clinical trial?

Bad news on their ALS drug, if I recall. Also, funding fears.

Neuralstem (CUR) Halted on LUDP After Announcing Phase 2 NSI-189 Data Now Expected Ahead of Schedule.

Replying to yeahisaid · Well, they got 20 million recently.

Yep, I think they will see it through. They dipped like crazy yesterday, due to their CFO leaving/being fired. I knew it was an overreaction, though. So I bought more. It's already up 33% today!

Neuralstem (CUR) Halted on LUDP After Announcing Phase 2 NSI-189 Data Now Expected Ahead of Schedule.

Replying to bcho86 · What share price did you jump in on /misteryouaresodumb? I'm heavy in biotech stocks at the moment and there's no DD on Reddit besides anecdotal reviews.

My average share price is about $3.33. I have sold and bought on the chop a few times. Some of those trades have been good. Some have been a little shortsighted. I'm up about 80% at the moment.

Neuralstem (CUR) Halted on LUDP After Announcing Phase 2 NSI-189 Data Now Expected Ahead of Schedule.

Replying to ecoBranden · Anyone make an investment in Neuralstem?? How confident are you in it?

If they can keep getting funding, it's going to explode. We all know NSI-189 works. That's no question at this point. The only question is whether or not Neuralstem is going to run out of money before they can bring it to market. This is why it is high risk, high reward. I'm heav…

NSI-189 to restore feeling of pleasure.

Replying to EhOhEl · Hahahaha, tough luck, mind if I ask how much you put into CUR?

Only $5K. I was just messing around with it, not really investing. I don't have the time to properly day trade.

NSI-189 to restore feeling of pleasure.

Replying to inmy325xi · Ahhh I'm gonna hold on a bit longer. I really should of sold same day. But I figured I'll wait til I'm pass the capital gains tax duration. (1yr) and take whatever profit I have. …

Yeah, I am kicking myself for getting out too early!