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Comment · Tue, June 9, 2026 · ND Owner

Concerns about Cistanche Supercritical Extract & Steroidogenesis: Does Acteoside/Verbascoside actually drop Testosterone? (Looking at this 2015 study)

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CitronOk9793 · 11 points

Hey everyone,
I've been planning to refine my supplement stack for steroidogenesis, and like many here, I always assumed \Cistanche tubulosa\ was a definitive "pro-testosterone" herb. I've taken it for years from them, to good effect. Including the super critical I find very energizing .

However, I recently came across this 2015 study from \Molecular & Cellular Toxicology\:
\\"Acteoside reduces testosterone by inhibiting cAMP, p450scc, and StAR in rat Leydig cells"\\ (https://link.springer.com/article/10.1007/s13273-015-0002-x)
For those unfamiliar, \*\acteoside\\ is just another name for \\verbascoside\\*. The researchers found that isolated acteoside actually \reduced\ testosterone production in rat Leydig cells by down-regulating cAMP and suppressing key steroidogenic proteins/enzymes like StAR (Steroidogenic Acute Regulatory protein) and p450scc (cholesterol side-chain cleavage enzyme).
This has me somewhat concerned, especially when looking at higher-end extracts. For instance, Nootropics Depot’s \*\Supercritical CO2 Cistanche Extract\\ is standardized specifically to be very high in \\acteoside\\*. If isolated acteoside suppresses the fundamen…

What they were answering

Warren_sl · 3 points

Aside from the nitty gritty of the operations and the shit you’ve been through you’re living the dream compartmentalized to that post haha

u/MisterYouAreSoDumb · ND Owner

We are certainly doing some really cool shit, that's for sure!

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