Is it true that saffron can build up to toxic levels in your system if taken daily?

Saffron supplements are considered safe and do not build to toxic levels in the body when consumed in typical dosages. Research indicates that saffron and its constituents have low toxicity in normal cells and are even non-toxic when administered orally.

The toxicity of saffron \(Crocus sativus L.\) and its constituents against normal and cancer cells

Interestingly, it seems that saffron toxicity is selective and target only cancer cells. Since, according to the international classification, LD50 between 1 to 5gr/kg is practically considered as low toxicity and more than 5 gr/kg as non-toxic [95], [96], saffron and its constituents, at least can be regarded as “with low toxicity” substances. Moreover, it seems that some toxicities such as gastrointestinal symptoms and bleeding only occur with injection of saffron and its constituents. Hence, they can be considered as “non-toxic” at oral intakes [76], [88], [89], [90].

So saffron is very safe orally up to 1.5 grams per day. Any toxicity issues seen in studies were in crazy high doses (>5g per day), or via injection. Our capsules are 30mg, so you are perfectly fine taking them daily.