Comment · Fri, June 28, 2024 · ND Owner
Broken epicatechin tablets
Original post in this thread
Warren_sl · 12 points
I love this product, but oh my, I feel like every fifth tablet is split in two or crumbled into Pieces this batch, last batch I’d bought was still enteric coated.
What they were answering
chris106 · 3 points
I'm all for acid resistant capsules compared to tablets.
Not to hijack this, but can you disclose what the acid resistant capsules are made of/coated with exactly?
As I like to fill my own capsules, I found one german supplier who sells supposedly acid resistant caps. These are the first ones I came about that actually feel different (to the touch).
Still unsure if they are legit though. It only states they are made of hyprommelose and gellan gum(the latter as the rough-feeling coating, I guess)
u/MisterYouAreSoDumb · ND Owner
As I like to fill my own capsules, I found one german supplier who sells supposedly acid resistant caps. These are the first ones I came about that actually feel different (to the touch). Still unsure if they are legit though. It only states they are made of hyprommelose and gellan gum, the latter being the rough-feeling coating, I guess.
They will probably fail our testing, unless this is a pharmaceutical capsule manufacturer. However, they refuse to sell to you unless you have a pharmaceutical manufacturing license. Literally everyone else we have tested has failed. Every single finished product on the market, other than our tablets, fails our dissolution testing. Every single manufacturer of capsules claiming to be acid resistant or enteric fails our testing for enteric. The longest we have gotten an acid resistant capsule to last in simulated gastric fluid is 30min. That's the best of the best. That being said, one of our manufacturers thinks they have solved it finally. I am not putting money on it, but they are in our lab right now for testing. We shall see soon!
As for what they are made of, it's HPMC, or hydroxypropyl methylcellulose. The difference is the polymers used. They form the HPMC polymers in such a way that it adjusts the pH that they dissolve at, or just make them last longer than usual at low pH. The big issue is that polymer science is closely guarded by the pharma industry, so they really keep it all tightly controlled.