Comment · Fri, December 23, 2022 · ND Owner
Cognance: waste of money
Original post in this thread
Neurogence · 33 points
I had taken a break from all nootropics for about two years or so. Recently I got back into dabbling, and saw quite a few positive posts on cognance. So I decided to try it out. I've been taking it for about two weeks now with no noticeable results. I tried to increase it to 200mg but still not noticing anything.
Originally, I had stopped taking mostly all nootropics due to lack of effects. I'm afraid all these new substances also have very negligible effects. I've tried hundreds of nootropics. The substance I've benefitted from the most is aniracetam, but I don't know where to find it these days.
How are you all experiencing positive and even "tangible" effects from substances like cognance? Is this all placebo? I don't buy the idea that everyone's biology is different. Substances that are effective have an effect on mostly everyone (example, caffeine). Whether positive or negative, you will feel something from caffeine. But most of the nootropics out there I barely feel anything from them. At this point I don't know what the difference is between something like cognance and a sugar pill.
What they were answering
AurisAsas · 2 points
Are nootropics lost cause for chronic non-responders? Is there hope for them?
u/MisterYouAreSoDumb · ND Owner
Since we don't fully understand what makes someone a non-responder, I don't think we can answer that. Still, just because someone doesn't consciously notice something doesn't mean it isn't still working in the background. All this talk of placebo responders/non-responders is generally in relation to self-reported studies like depression, anxiety, and pain. If someone is a chronic non-responder to things consciously affecting their psyche, that doesn't mean they are not getting benefits they are not consciously noticing. This is where binding studies and more objective direct measurements come into play. If we know a particular compound binds in a certain way, and we know that it has specific pharmacokinetics in humans, and we know that mechanism has X effect, then we can assume they might be getting those benefits even if they don't notice them. Still, people take things because they want to feel an effect. If someone is taking something and not feeling the effect they want, then even if it is providing benefits in the background, they probably won't keep taking it.