Comment · Fri, December 16, 2022 · ND Owner

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NDSocialMedia · 45 points

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What they were answering

tak653 · 6 points

Is there any chance that we will get OptiNAD+ with the updated quercetin phytosome?

u/MisterYouAreSoDumb · ND Owner

Potentially. We are also working with Indena on some new phytosomes that could be good in it, too.

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We almost never use maltodextrin in our formulations. We purposely avoid it, not because of compelling science, but because it is just easier to agree and move on than fight that fight. However, what most consumers don't

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Curcumin, Fisetin, Apigenin, and Quercetin all seem to work via this pathway as well. [Inhibition of PI3K/Akt/mTOR Signaling by Natural Products](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775843/)

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Replying to EpictetanusThrow · Which supplements from ND are AMPK activators?

Quercetin, hesperidin, berberine, NMN, CoQSol-CF, EGCG, epicatechin, nobiletin, curcumin, etc.

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Replying to xabgt · You have commented in other reddit threads, that AMPK stack heavy is too stimulating. It is not necessary add other stimulants like coffee, ... What supplements to add in one AMPK …

Hesperidin, EGCG, CoQSol-CF, NMN. I personally would add in quercetin, berberine, and epicatechin, too. However, that is more than 4.

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Replying to LucGuzotte · Thank you for the suggestions. I got her some Longvida, tart cherry extract, and quercetin to add to her supplements. Hopefully that will help. I will definitely look at the others…

Those are great ones. Let me know how it works!

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It looks like curcumin increases EGCG's effects! https://link.springer.com/article/10.1186/s12906-019-2545-1 So does quercetin! https://pubmed.ncbi.nlm.nih.gov/22452782/

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