Comment · Fri, July 29, 2022 · ND Owner

Does Pyroglutamic Acid increase Glutamate?

Original post in this thread

IncreasinglyTrippy · 16 points

I’ve seen it mentioned that it increases gaba but I’ve seen some folks argue in other subs whether it raises glutamate and I can’t sort it out.

While we’re here, any idea what’s the dose range or max dose?

Any potential downside for L-Pyroglutamic Acid or interactions to be aware of?

Thanks

What they were answering

IncreasinglyTrippy · 3 points

Fascinating.

I think it’s been really helpful for my anxiety/adhd. That or Agmatine, or both. Trying to pin it down and understand it.

Pyroglutamic acid doesn’t interfere with sleep if I take it late in the day right? I’m assuming since it’s in alcohol defense it is most often taken before bed.

u/MisterYouAreSoDumb · ND Owner

Well the Alcohol Defense has glycine in there to try to counteract that. It might affect some people's sleep, but honestly I have not personally tried it before bed on its own.

Other MYASD lines in this thread

Comment · Wed, July 27, 2022 · 7 pts
Pyroglutamic acid has been shown to release GABA from the cerebral cortex, and displays anti-stress effects in a simple approach-avoidance conflict situation in rats. In clinical pharmacology experiments, pyroglutamic ac

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