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Comment · Sat, June 26, 2021 · ND Owner

⚠️ NEW PRODUCT ALERT | Ginkgo Biloba powder | 10% Kaempferol Glycoside + 2% Bilobalide ⚠️

Original post in this thread

NDSocialMedia · 46 points

What they were answering

zidatris · 14 points

Wow, awesome! How is this different than the ubiquitous and well-known 24% flavone glycosides and 6% terpenes extracts?

u/MisterYouAreSoDumb · ND Owner

The 24% and 6% standardization is just copying EGb-761, which was an initial extract standardization that has many studies behind it. However, the 24% and 6% numbers are not specific enough for me. We have tested a lot of ginkgo out there, and the actual amounts vary drastically from extract to extract. Two extracts might both meet the 24%/6% claim, but the amounts and ratios of the actual flavone glycosides and terpene lactones mean each extract feels totally different. One big one is bilobalide. It's one of the most interesting terpene lactones in ginkgo biloba. However, we found many extracts that had none or barely any, even if they met the 6% claim for total terpenes. So rather than just group all of them together like they are the same, we decided to make an extract where you always know you are getting a good dose of bilobalide itself, and not some other terpene lactone. Plus, you can spike extracts with cheaper terpenes to get that number up. Looking directly at bilobalide prevents that. Ginkgo biloba is one of the most adulterated plant extracts on the planet. Using cheap ginkgo extracts and spiking them is happening literally the majority of the time. It's crazy. Everyone is just trying to hit 24%/6%, and they are using shady ways of doing it.

So that's the terpene story. What about the flavone glycosides? Well rather than just looking at total flavone glycosides, we look specifically at kaempferol. Kaempferol is a flavone glycoside with a lot of interesting effects. The other main one in gkinkgo is quercetin. However, we already have a high quercetin standalone product, so we would rather focus on the kaempferol side of things for the ginkgo extract. Kaempferol binds with vascular endothelial growth factor (VEGF), which causes angiogenesis. That's where new blood vessels form in the body. Kaempferol also strongly potentiates endothelial nitric oxide synthase (eNOS), which is responsible for the vasodilation properties. This means that if we want a ginkgo that is consistently targeting the main mechanisms we are looking for, bilobalide and kaempferol are the ones we want to standardize to. You could take a cheap ginkgo extract and add in rutin/quercetin and a cheap terpene like limonene to reach the 24%/6% standardization, but it won't give you anywhere near the effects you are looking for, and certainly nothing like the effects found in the studies on EGb-761. I am not kidding when I say that ginkgo biloba is one of the most adulterated products on the market. Over 75% of extracts tested failed to meet their label claims in Consumerlab testing. It took us a while to get an extract in that met all our specs and testing. Extract-to-extract testing showed that the bilobalide and kaempferol levels can range up to 5X between extracts, while still meeting the 24%/6% numbers. Our extract will always be consistent batch-to-batch.

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