Question about Injuv: why is the HA content so low compared other on the market?

200mg of high molecular weight hyaluronic acid is pretty much useless. Your body can't absorb it, so it just passes through your system. Taking higher dose of something you can't absorb is just a waste. Injuv is put through an enzyme cleaving process that reduces the molecular weight of the HA particles, allowing them to absorb into your body. The HA particles in Injuv are between 1.5 and 5 kDa. That's 1,500 and 5,000 Daltons, which is less than 1% of their original size. Bacterial hyaluronic acid, the kind in the NOW product, is between 1000 and 4000 kDa. That's 1,000,000 and 4,000,000 Daltons, respectively. So you are talking the difference between 1,500 Daltons particles and 1 million Dalton particles. The Do Not Age product doesn't even list where the HA is from, other than saying high molecular weight, which means it is likely in the 4,000,000 to 8,000,000 Dalton range. They state the following:

Hyaluronic acid of high molecular size stops cancer cells from growing and stops your immune system from overreacting. Low molecular weight hyaluronic acid can cause inflammation, so it is vital that high molecular weight is the one you consume.

For one, that's total bullshit. There are studies in naked mole rats that show high molecular weight HA does suppress oncogenic transformation. However, that's because naked mole rats produce high molecular weight HA endogenously. Taking exogenous high molecular weight HA won't even get into the body, so it certainly won't "stop cancer cells from growing" like they claim. That's also irresponsible and a violation of FDA guidelines to make a disease claim like that. Preying on people with cancer to try and convince them their product will stop cancer cells from growing is sick. Doing it with a misinterpretation of the science is just plain stupid. We are not naked mole rats, and using a study of endogenously produced high molecular weight HA as evidence that exogenously supplemented high molecular weight HA can prevent cancer growth in humans is just wrong. Injuv has a double-blinded placebo-controlled study in humans showing it increases the moisture content of skin. That's the gold standard in science. If you have a double-blinded placebo-controlled human study showing a statistically-significant effect, you can be a lot more confident in the results. Moreover, those naked mole rat and in-vitro studies were not meant to show efficacy of some supplement. They were meant to study and elucidate the role of hyaluronic acid in various processes. Trying to bastardize those scientists' findings to fit some marketing claim on a supplement just means they are either scientifically illiterate, or they are willfully misleading people to sell their product. I really really hate when companies misinterpret science and make grandiose disease claims on their products. It harms our entire industry, and preys on people fighting diseases that are looking for any possible route that can help; not to mention puts more FDA scrutiny on dietary supplements in general.

So you are comparing apples to oranges. Injuv has clinical research showing it improves skin moisture content when taken orally. Low molecular weight hyaluronic acid is different than high molecular weight hyaluronic acid. Does that mean the NOW stuff is useless? No, it probably does get some into the body at that dose. However, you are getting much higher molecular weight HA particles, which affects how it acts in the body. At least NOW is not saying it will stop cancer growth.