Comment · Mon, February 15, 2021 · ND Owner

ETA on Ginger and Gingko Biloba extracts?

Original post in this thread

TheOptimizzzer · 15 points

Sorry if this has been asked about lately, but I couldn’t find anything on them. I think these had been mentioned a while back as priority ones in the pipeline. u/misteryouaresodumb are you able to provide any update on these or any teasers on anything else being released soon?

Thanks!

What they were answering

xRedHairing · 3 points

I am very, very excited to try the ginger extract. Any idea as to how strong of a 5-HT3 antagonist it may be?

u/MisterYouAreSoDumb · ND Owner

It seems to be a non-competitive 5-HT3 inhibitor.

Ginger and its pungent constituents non‐competitively inhibit activation of human recombinant and native 5‐HT3 receptors of enteric neurons

Mode of action of gingerols and shogaols on 5-HT3 receptors: Binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum

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