Comment · Wed, November 4, 2020 · ND Owner
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Original post in this thread
NootropicsDepotCom · 19 points
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What they were answering
1tsn0tme · 2 points
From what I understand Ethyl Ester is inferior to triglyceride form. But this product is different because it’s micellized?
u/MisterYouAreSoDumb · ND Owner
Inferior is not exactly a scientific explanation. It's much more complicated than X is good and Y is less good. Triglyceride forms are similar to ethyl ester forms. They are both classified as esters. Triglycerides are bound to a glycerol backbone. Ethyl esters are esterified to an ethanol backbone. Most of what is naturally found in fish oil is the triglyceride form. There are some free fatty acids, but most of it is in triglyceride form. The issue with triglyceride forms is that you don't get very high EPA/DHA. This is where converting to ethyl esters and concentrating comes into play. That is how you can get the high levels of EPA and DHA like we have in our fish oils. This also affects how it can work in the body, as the process of hydrolyzing ethyl esters is slower than that for triglycerides. So you get a slower and more sustained release. Triglycerides are hydrolized quicker, so you get a larger peak in plasma levels, but they are not as sustained. Triglyceride forms of fish oil are slightly more bioavailable (~20-30%). However, their AUC is shortened. So you get a quick peak and then a quick drop off. Ethyl ester forms absorb slower, but are more controlled in release. So while you will get higher peak plasma levels with the same dose of a triglyceride form compared to an ethyl ester, the effects don't last as long. Pair that with how much more expensive triglyceride forms are, and it just makes more sense to have a higher dose of an ethyl ester form.
Accelon is very different because it is in micelle form. So you get the benefits of the ethyl ester form, but also the improved bioavailability. It's literally the best of both worlds, because you keep the sustained-release aspect of your body taking time to hydrolyze them, while also improving peak plasma levels to over that of a triglyceride form.