Comment · Tue, November 3, 2020 · ND Owner
⚠️ NEW PRODUCT ALERT | Accelon Omega 3 Fish Oil Softgels | 500mg ⚠️
Original post in this thread
NootropicsDepotCom · 19 points
​
Accelon Omega 3 Fish Oil Softgels | 500mg
Use coupon code NDSUBREDDIT for 10% off your total order.
CLICK HERE TO BUY ACCELON OMEGA 3 FISH OIL SOFTGELS FROM NOOTROPICS DEPOT
What they were answering
NotReallyAPenguin · 3 points
I had a question about the description on the product page:
Typically, people take Omega 3 supplements with food, so this requirement is no longer needed, meaning getting your daily DHA and EPA has never been easier and more convenient! Even if taken with food, Accelon™ absorption is still more than 30% greater than with other Omega 3s. Making Accelon Omega 3 one of the best Omega 3 supplements on the market for optimizing absorption!
I get that on an empty stomach it absorbs 4x better, but if I was already taking Omega 3 with food, is this product only 30% better? Just trying to figure out whether this makes more sense than the triple strength caps you sell, which after a 30% adjustment would be slightly higher in EPA but slightly lower in DHA.
u/MisterYouAreSoDumb · ND Owner
That's reducing the complexity down a bit, but kind of. This will provide a better improvement in bioavailability to those people taking their fish oil in a fasted state. If you look at the data in the study I posted above, you can see it actually improved EPA by a factor of 23.6, on average! It was a factor of 3.6 for DHA. So it is actually improving EPA absorption a LOT more than the 4X number alludes to.
Individual baseline-corrected dose-normalized EPA and DHA exposure pharmacokinetic parameters were presented in Tables 5 and 6, respectively. For EPA, PRF-021 exhibited a 7-fold higher Cmax and 24-fold higher AUC0-24h vs. control in Study 1 and a 9-fold higher Cmax and 26-fold higher AUC0-24h vs. control in Study 2. For DHA, Cmax was approximately 2.7-fold higher and AUC0-24h was 3.6-fold higher vs. control in Study 1 and Cmax and AUC0-24h were increased more by 4.3 and 5.6 times, respectively vs. control in Study 2. The relative absorption improvement is more pronounced for EPA than for DHA in both studies.
Then you have this study: https://www.clinicaltherapeutics.com/article/S0149-2918(18)30509-5/fulltext
That shows 8.2-fold higher EPA/DHA than standard fish oil. So the 4X number is absolute minimum improvement. The real world improvement is actually much higher than that.