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Primavie shilajit should help.

The Human Skeletal Muscle Transcriptome in Response to Oral Shilajit Supplementation

Ashwagandha, too.

Evaluation of anti-inflammatory effect of Withania somnifera root on collagen-induced arthritis in rats

Cissus quadrangularis has similar efficacy as ashwgandha for type 2 collagen.

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling

To overcome OA disease progression, production of cartilage regenerative molecules that assist cartilage resynthesis is critical. Gene expression of type II collagen and aggrecan, the building blocks of cartilage, was evaluated and was observed to significantly increase in levels upon treatment with herbal extracts (Figure 3C). W. somnifera significantly increased gene expression of type II collagen and aggrecan by tenfold and twofold, respectively, as compared to IL-1β-only treated cells. C. quadrangularis showed similar activity in which type II collagen and aggrecan were upregulated seven- and twofold, respectively. Survivin, a member of the inhibitor of apoptosis family, is associated with inhibition of cell apoptosis and promoting cell growth.24 Recent work has shown upregulation of survivin aids in chondrocyte proliferation and viability.13,19 As shown in Figure 3C, treatment with C. quadrangularis and W. somnifera induced survivin expression by fourfold and 2.5-fold, respectively, as compared to untreated (IL-1β-only) cells. Interestingly, inhibitory activity of herbals on inflammation-inducing pathways such as NF-κB and MAPK were also observed (Figure 3D). NF-κB was downregulated with all herbals and the combination treatment reduced expression of extracellular signal-regulated kinases (ERK)2 and p38 MAPK signaling. No significant change, however, was observed with the JNK pathway. The involvement of NF-κB (Bay 11-7082 at 5 μM) and p38 MAPK was further confirmed by using specific inhibitors (Figure 3E). There was a complete inhibition of these two important cell-signaling molecules confirming their roles in C. quadrangularis and W. somnifera treatments.

We are working on a cissus quadrangularis extract of our own at the moment, along with our own ashwagandha.

Curcumin also has type 2 collagen effects.

Curcumin protects human chondrocytes from IL-1β-induced inhibition of collagen type II and β1-integrin expression and activation of caspase-3

>To evaluate the production of the cartilage specific matrix marker collagen type II, the APAAPARTICLEINPRESSM. Shakibaei et al.490
method was employed. Chondrocytes were seeded on glass plates and then either treated with 10 ng/ml IL-1balone for 5, 15, 30 min (Fig. 2B–D) or pre-stimulated with 10 ng/ml IL-1bfor 30 min before being co-treated with 10 ng/ml IL-1band 50mMcurcumin for the same time periods (Fig. 2E–G).Control cultures were untreated (Fig. 2A). Positive labelling of collagen type II was visible around the chondrocytes in the control chondrocyte cultures(Fig. 2A). Stimulation with 10 ng/ml IL-1bled to decreased collagen type II immuno labelling around the chondrocytes in a time-dependent manner(Fig. 2B–D). Co-treatment with curcumin appeared to increase collagen type-II production (Fig. 2E–G).

We actually suggest Longvida and Sensoril in our joint health stack. If you have not seen our stack guide yet, take a look. My team did a good job of helping people choose stacks for specific effects. You choose beginner, intermediate, or advanced. Then you choose the effect you want, and it suggests a stack for it.

https://nootropicsdepot.com/stack-recommendations-index/