Comment · Sat, February 22, 2020 · Nootropics Depot
Bad batch from liftmode?
Original post in this thread
Data_Destroyer · 1 points
I normally order through nutravita (I think it's the strongest) but they raised their prices recently so I went back to liftmode. Well, I dunno if the batch I got was bad or if their overall quality has gone downhill, but my usual dose is not even close to cutting it. It seems to be 50% as strong. I took 50% more today and got almost nothing out of it. I know tolerance builds fast but it doesn't build by that much in literally one day.
Has anyone else had an issue like this? They claim its 99% pure... How could it be half as strong as nutravita's?
What they were answering
big_wendigo · 1 points
So u/MisterYouAreSoDumb says that all commercially available phenibut (that’s not specifically labeled as R-phenibut or S-phenibut, of course) is racemic, but I wonder what causes the difference in potency. I’ve definitely used one batch for a while and then switched to another and got much better effects.
I was reading up on the subject a little, and a non-racemic mixture has something called enantiomeric excess. It’s the difference between stereoisomers/enantiomers. For example, if there was 25% of S-phenibut and 75% of the R-phenibut, the enantiomer excess would be 50%.
Anyways, I still wonder if the mixtures aren’t exactly racemic when we get them. It would be cool if there were some test results out there that gave us an example.
u/MisterYouAreSoDumb · Nootropics Depot
ALL phenibut in the world is racemic. There is not a single supplier selling R-phenibut in the entire world. Noofen is racemic phenibut like everything else. I have some right next to me, in fact. Racemic also means 50/50. You can have other mixtures of enantiomers, but they don't arise naturally from most industrial syntheses. The synthetic route determines what enantiomers you get. If you use enantiopure precursors, and use an enantioselective synthesis pathway, then you can get specific/different amounts. However, those are specialized synthesis pathways that you need to set out to use, and they are not as efficient as the more simple industrial pathways used. You are not going to be dealing with any enantiomeric excess in any common phenibut synthesis pathway used today.