Comment · Fri, December 27, 2019
Ashwagandha extract withanolides composition
Original post in this thread
Aldarund · 3 points
Is there data available on composition of ND ashawagandha extract ( not ksm or sensoril)
E.g. Withanolide A, Withaferin A, Withanoside IV etc.
What they were answering
Aldarund · 1 points
They imply that Withaferin A is cyto toxic, and thats why their extract better and safer.
### 2. Make sure that you assess the concentration of cyto-toxic Withaferin A.
Not all withanolides are beneficial. Withaferin A is one withanolide which is cytotoxic, as has been established in multiple scientific studies. So, it is undesirable to have Withaferin A in an ashwagandha extract when the intended use is for classical applications like building anti-stress ability, energy, cognition and immunity. Some ashwagandha extracts have high levels of Withaferin A because the manufacturers use ashwagandha leaves. Using leaves spikes up the overall withanolide content, but it also brings in the undesirable withanolide ‘Withaferin A’. KSM-66 consists of negligible levels of Withaferin A, making it very safe for human consumption.
(c)
u/MisterYouAreSoDumb
Sure, but that is why it is anticarcinogenic. Cytotoxicity is not inherently bad if it is targeted at cells like cancer.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023354
https://cancerres.aacrjournals.org/content/68/18/7661.short
https://link.springer.com/article/10.1007/s10495-008-0273-y
https://academic.oup.com/carcin/article/32/11/1697/2463698
https://www.tandfonline.com/doi/abs/10.1080/01635580802381477