Comment · Tue, November 19, 2019
Kanna (zembrin) / Saffron
Original post in this thread
RSGC9 · 10 points
Have a few questions so I'll consolidate into 1 thread.
1. Read that you are not going to restock zembrin, when will the kanna be available?
2. Saffron has been gaining popularity, especially with the study that gave comparable results to Ritalin. Any plans on stocking it soon?
3. Been suffering from depressive/fatigue symptoms for years. I've tried all kinds of stuff from racetams to adaptogens to the more exotic stuff like bromantane, tianeptine, nsi-189, cbd etc mostly from ND.
Had a old bottle of zembrin from you guys, decided to try 25mg a few days ago and it was life changing. Depression melted away, didn't realise how much anxiety was affecting me and how dysfunctional my cognition was. Anyway, since I respond well to it I wanna know what other stuff you guys sell that would work on the same MOA as zembrin for me
What they were answering
RSGC9 · 1 points
1) any eta on it? I'll probably finish the zembrin in about a few weeks time and I'd prefer to buy from you.
2) Cool, good to know.
3) 25mg sublingual. First day I took it had a pronounced effect on my anxiety. Didn't realise I suffered from it for so long.
By the 3rd or 4th day, my fatigue was gone . For the longest time, all I'd do after work is go home because I was too tired. I wanted to go out and socialise / take classes to upgrade myself but I just couldn't. The motivation to do all these is back. I suffered from overeating where I couldn't be in a deficit at all no matter how hard I tried. I can eat less with no problems now as well.
It's been about a week, the acute effects have definitely built a tolerance but mood/anxiety/anti-fatigue effects still here. Any stuff I can take to prevent tolerance? Or similar MOA I can cycle with. Thanks man
u/MisterYouAreSoDumb
1) It's hard to give ETAs when the lab data is what is holding it up. It certainly will be longer than a few weeks, though.
What else have you tried? Anything else give good results? The mesembrenone in Zembrin is pretty unique in its MOA. It is mainly PDE4 inhibition. The issue is that a lot of PDE4 inhibitors have a lot of side effects, or act in the wrong part of the body for mood enhancement. So mesembrenone is pretty unique in that respect. It could also be the SRI effects of the mesembrine as well, or a combination of both working together. Your comment on overeating makes me think serotonin is coming into play at least some, as that's a common target for overeating. A good saint john's wort might be good for you. Perika is standardized to hyperforin, and that up-regulates serotonin though the sodium channels. Polygala might be another one you respond well to.