Comment · Thu, August 22, 2019 · Natrium Health & Nootropics Depot
My first experience with oleamide.
Original post in this thread
drop0dead · 12 points
I decided to grab some of this to get the free shipping through ND. I didn't expect much as there seems to be very few reports and even less stating an effect. I think its important to mention that I've been consuming cannabis for approximately 9 years, more recently mostly at night to help me fall asleep. My sleep quality has been pretty bad the last few months due to stress and a few other personal issues. I typically will end up taking a sleeping pill once or twice every two weeks just to feel like I got a restful night. Last night about an hour before I cut off the tv and went to bed I took 105mg of oleamide powder (more like wax pellets/beads). I put it under my tongue for about 10 minutes and to my surprise most dissolved but it was horrible tasting. Going to bed and falling asleep I barely felt any effects, slightly felt easier to get my head into the sleep space and not keep thinking about the day/week. After I fell asleep is when it truly shined. Typically I'll sleep for an hour and a half or sometimes 3 hours and then wake up reposition and try to go back to sleep. And then at some point in the night I'll get up and feed my cat. Last night I slept four and a half hours s…
What they were answering
kylekingsly · 1 points
Thanks bro, that's dang smart of you to check out the CoA and dang disappointing of /u/liftmode to sell such a partially inactive product. Maybe they can fimd a better supplier in the future?
BTW, you didn't mention /u/Misteryouaresodumb properly, that's how you do it. Hopefully he can chime in about what ND's oleamide consists of exactly.
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
Our oleamide is 100% cis isomer. It took us a while to find. Most oleamide out there is for industrial use as a lubricant. They don't care about isometric purity, since both isomers lubricate in a similar fashion. Both isomers don't act in a similar function in the body, though. This is why it took us a while to bring it out. We had a lot of sourcing issues, then a lot of analytical testing issues; as actually testing the identity, purity, and isometric purity of cis-oleamide is difficult. The peaks for oleamide on an HPLC are pretty weak, and they overlap with similar structured fatty acids. So we went with GC/MS, as that provided better separation. Then we used FTIR to determine isometric purity. Trans-oleamide will have a peak at 960 cm-1 that will not be there in cis-oleamide. That peak is due to the trans substituted alkene group that does not exist in the cis isomer. Then NMR is used to definitively confirm, as the proton signals look different between the isomers; with the trans having two overlapping double split triplets at the double-bond region instead of a triplet-triplet for the cis.
Nobody out there is testing oleamide properly. We had to use 3 labs, plus internal testing, to confirm this stuff. We asked literally everyone you can think of, and they all did not do proper testing. This is one of the main reasons I have been building out our lab so much. I really don't trust many people these days. I only trust what I can see and verify with my own eyes, and what I can personally ensure is being done properly. I watched our equipment manufacturers do the couple hundred page IQ/OQ on our machines. I watch my team run the methods and sample prep. I sit with my lab director and go through the data. I know everything going on in my lab. I can't get that data from most other labs. They either refuse, or give us really shitty documentation. The day when I can run ALL methodologies in my own in-house lab will be a happy day for me. We are getting close. I likely will always contract out NMR, as we have a good local lab that does it for us now, and we do the data analysis. I can't justify spending $500,000 on an NMR when we have a good local lab we already work with. We also have a good local ICP-MS lab that does the same for us for heavy metals. I may one day get an ICP-MS in our lab, but that will likely be the last one we do. Next is headspace triple quad GC-MS/MS. Then a triple quad MS detector for our UPLC. My lab director is actually in Massachusetts this week at the headquarters of Waters. We are helping them to design their new triple quad UPLC-MS/MS machines. So hopefully we can get an R&D unit in our lab before everyone else!