Comment · Fri, February 9, 2018

Comprehensive Guide to the Best Anti-Aging Supplements

What they were answering

itsme-fasting · 3 points

Interesting article, thanks.

u/MisterYouAreSoDumb, any thoughts on the research on sirtuins and supplementing NAD+?

u/MisterYouAreSoDumb

The research behind NAD+ is interesting. However, I am not yet convinced that supplementation of nicotinamide riboside increases plasma levels enough to justify the cost. It seems to elevate it in the liver, but that doesn't seem to translate to systemic. Nicotinamide mononucleotide seems to be a better option, but I need to research more before I can confidently say it is worthwhile.

The same goes for the entire mechanism of sirtuins. It seems like a big breakthrough, and some animal models show seriously extended lifespans by targeting sirtuins. However, I have not done enough research to confidently say one way or another. Does it translate to humans? Do the existing compounds targeting those systems work in the prescribed dosages, or do we need more potent ones targeting specific types, like SRT1720? Does it fuck with our systems protecting us from things like cancer?

Other MYASD lines in this thread

Comment · Fri, February 9, 2018 · 2 pts
I remember that. It certainly could have been a response your body had to increased NAD+ levels in your liver causing some sort of signal cascade. Then perhaps your body got used to it, and you never felt it again. I wou

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