Comment · Mon, January 15, 2018 · Ceretropic & Nootropics Depot
Unexpected Nephrotoxicity in Male Ablactated Rats Induced by Cordyceps militaris: The Involvement of Oxidative Changes
What they were answering
Direct reply to the original post in this thread.
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Herein, we carried out the 28-day repeated toxicity test in male and female ablactated rats (three weeks old) given C. militaris powder orally at 0 (control), 1, 2, and 3 g/kg per day.
Holy shit, 1, 2, and 3 GRAMS per kg dosages?!? Even using the most generous conversion factor, that's a 13 gram per day dose for someone my body weight at the lowest dosage. Furthermore, the increased ALT and AST levels were only seen in the 2g/kg and 3g/kg groups. So that would be like me taking 26 grams and 39 grams per day. They also show that males were more susceptible, and posit that it is due to cordyceps increase in sex hormone levels.
In the present study, the increment in GSSG/GSH ratio in kidneys was found after CCM treatment. The alteration in the activities of these enzymes, together with the alteration in the GSH/GSSG system, reflects that CCM can induce alterations to the oxidative system in the kidney. These differences may be related to the sex hormones which play an important role in acute kidney failure. For example, there is a gender difference with regard to the severity of hepatic oxidative stress in acute uremia, with female rats displaying significant protection relative to male rats [20]. Moreover, the toxicity of doxorubicin was much stronger in male rats; toxicity was diminished after castration, which is known to downregulate the expression of renal OAT1 in rats [21, 22]. In the future, models such as orchidectomized males and ovariectomized females will be used to shed light on the role of hormone in the nephrotoxicity induced by C. militaris.
I laughed at their single sentence remark in the conclusion about the dose...
Although the toxic dose level was relatively high, it is enough to arouse the public attention on the safety of herbal medicine.
Yeah, I'd say 26-39 times the normal dose is fairly high! Haha. So if you are a dude, probably don't take 26 grams or more a day of cordyceps...