Comment · Tue, November 28, 2017
Separating the agony from ecstasy: R-MDMA has prosocial and therapeutic-like effects without signs of neurotoxicity in mice
What they were answering
wagonspraggs · 3 points
It stated pretty clearly in the results that the mice pulled out glow sticks and began to dance vigorously.
Jokes aside: this R enantiomer is the one responsible for the 5ht2a agonism magic (S had no affect) but is about half as potent in releasing NE and 5HT as the S so larger doses are required. Though without dopamine i may have to agree that it won't be the same
u/MisterYouAreSoDumb
The "magic" is more than just serotonin, or we would see similar effects with purely 5-HT releasers like MDAI; which we don't. Also, in PiHKAL, Shulgin clearly said that a mixture of both enantiomers was greater than each individually.
https://erowid.org/library/books_online/pihkal/pihkal109.shtml
This post talks about it as well: http://countyourculture.com/2011/05/23/mirrored-magic-mdma/
Honestly, I think the magic that people experience with MDMA is a multi-system thing across different brain regions that requires balance between 5-HT, DA, and NE in just the right areas, which causes a signal cascade. If you miss one of them, you do not set off the signal cascade. You still get the obvious effects from whatever you are hitting, but the "magic" is not there.