Comment · Tue, November 28, 2017

Separating the agony from ecstasy: R-MDMA has prosocial and therapeutic-like effects without signs of neurotoxicity in mice

What they were answering

Sardinops · 12 points

/u/misteryouaresodumb

u/MisterYouAreSoDumb

Very cool study. I will have to read it in full when I have some time. They do theorize that lower dopamine release is the likely reason for it, and Shulgin mention that a mixture of S-MDMA and R-MDMA is key to getting the "magic." So while this study does point to R-MDMA being less damaging, I doubt they asked the mice how good of a time they were having. So it could maintain the pro-social aspects, but not have the "magic" in humans.

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Comment · Tue, November 28, 2017 · 8 pts
The "magic" is more than just serotonin, or we would see similar effects with purely 5-HT releasers like MDAI; which we don't. Also, in PiHKAL, Shulgin clearly said that a mixture of both enantiomers was greater than eac

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