Comment · Mon, July 17, 2017

Will a tolerance build to NAC's glutamate reducing effect?

Original post in this thread

NoveltyAccountsSuck1 · 3 points

I read that it induces the release of glutamate into the extracellular space where Group II mGluRs are located via the cystine-glutamate antiporter. And that these receptors are negative regulators of glutamate release.

Source from where I read this: https://en.wikipedia.org/wiki/Cystine#Biological_transport

So would there be tolerance to this effect?

What they were answering

JakeTHP · 1 points

Do you believe NAC can have negative long term properties? It's been mentioned as a possible carcinogen

u/MisterYouAreSoDumb

Are you referring to the below article for Scientific American?

https://www.scientificamerican.com/article/antioxidants-may-make-cancer-worse/

I'd say the mechanisms seem to make sense, and it should be considered if one has cancer. If some amount of oxidative stress is necessary to kill off cancer cells, then preventing that with stronger antioxidants could make things worse.

Other MYASD lines in this thread

Comment · Thu, June 29, 2017 · 1 pts
It's hard to say for sure. I would imagine there is some tolerance. However, it might allosterically modulate and maintain balance.

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