Comment · Mon, January 25, 2016 · Ceretropic & Nootropics Depot
Long-lasting downregulation of GABAergic synapses after repeated administration of anxiogenic drugs - possible implication for Fasoracetam?
Original post in this thread
I_Strahd · 5 points
Hello there,
I've been experimenting with a bevy of noots over the past couple years - and over that time, have remained consistently interested in fasoracetam for it's apparent potential in up-regulating the gaba system.
However, the use of gaba antagonists, for which this compound is considered, is still - in general - a mystery to me in terms of their long-term effect on an otherwise healthy brain.
Then today I happened upon this old study, which seems to make the case that:
"a long-lasting down regulation of GABAergic synapses can be obtained after repeated administration of anxiogenic, proconvulsant and convulsant negative modulators of GABAergic transmission. The latter finding further suggests that GABAergic synapses undergo rapid and persistent plastic changes when the GABAergic transmission is persistently inhibited."
http://www.ncbi.nlm.nih.gov/pubmed/1981393
and I'm left wondering...if fasoracetam's primary method of action is to antagonize gaba(b) receptors, will this, in actuality, have a negative impact on the functioning of the gaba system?
Similarly, will this mechanism hold,. in general, for all gaba antagonists?
And lastly, what is to be made of this c…
What they were answering
bananasownapple · 1 points
Hi I'm late to this post but I'm curious how permanent the GABA-B up-regulation is from fasoracetam
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Nothing is permanent. Your GABA(B) receptors will down-regulate again in response to stimuli.