Tianeptine Sodium dose once a day.

It's expensive. All the Tianeptine labs just raised prices for everyone across the board by 25-30%. However, we did not raise prices. We actually lowered sulfate pricing. The increase is because demand is outpacing supply. It's also why Powder City raised their Tianeptine prices. The sulfate uses the sodium in the synthesis. So you have the base cost of one, then the synth for the other.

While Shrillthrill is correct about the lack of human pharmacokinetic data, the sulfate salt is clearly longer-acting in most people. The solubility changes alone lead to that effect. Liftmode wrote a nice post about why that happens with the sulfate salt and with the free acid. It's not just because of the polymer release tablet in the patent application. It's the solubility change. Sure, the controlled release polymer would most likely lead to an improvement in those effects. However, without relative data that is only speculation. What is not speculation are the thousands of people trying it, and reporting longer lasting effects. If we had brought it out, and everyone reported that not happening, then I could chock it up to the tablet. However, that is not the case. There is a clear difference in the onset and drop in effects people report with just the sulfate salt as a powder. If there was not, I would not have so many people switching to it when they do back-to-back testing with the sodium.

There are so many things we talk about on here with lack of human pharmacokinetic data, or even lack of complete understanding of receptor affinities. Unifiram/Sunifiram, Coluracetam, NSI-189, Phenibut FAA, Fasoracetam, 9-Fluorenol, PRL-8-53, Phenyl/Piracetam Hydrazide, and all the modified peptides have a lack of adequate human studies. Yet we accept people's anecdotes as at least worth something with regard to effects and dosing amounts. Why should we treat Tianeptine Sulfate different, when it has been used by thousands now? If we wait for human pharmacokinetic data on everything, we would never have new things come out.

So while I agree that using the sulfate in pill form to deduce the exact half-life of the powder should not be done, I also think that we should not treat it the same as the sodium; just as we should not treat the free acid like the sodium. The onset, peak, and length of effects reported by the vast majority of people are very different.