Comment · Fri, October 30, 2015
MDMA + psychedelic combinations: An underrated risk?
Original post in this thread
tasty_cupcakes · 120 points
I was recently researching the potential health risks of MDMA + psychedelic combinations (also known as candyflipping, hippyflipping, etc.). While awareness of MDMA's potential neurotoxicity is very present in forums that promote harm reduction such as Erowid, /r/drugs, /r/mdma, Bluelight, DanceSafe, RollSafe, etc., there was not much discussion about the potential dangers of MDMA + psychedelic combinations. For example, on RollSafe, a site exclusively dedicated to MDMA harm reduction, cites MDMA+LSD, MDMA+Mushrooms and MDMA+2C-B as generally positive combinations without any kind of warning about the possible health consequences of those. Erowid recognizes that there has been no research on this front but doesn't especially warn about it.
While the scientific literature about MDMA + psychedelic combinations is very small, and centered on animal studies, this is some information I could find:
**Potentiation of (DL)-3,4-methylenedioxymethamphetamine (MDMA)-induced toxicity by the serotonin 2A receptior partial agonist d-lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C recep…
What they were answering
Borax · 2 points
TFW you realise they didn't use selective substrates when selectively discussing receptors
Thanks.
u/MisterYouAreSoDumb
Yeah, I've seen multiple studies claiming 5-HT2A were the cause of a certain effect, while using a compound that also has 5-HT2C affinities as the proof. It makes me wonder if it is something I am overlooking, something they are overlooking, or confirmation bias on their part.