Comment · Sat, May 16, 2015 · Ceretropic
Are there any issues with taking Semax for extended period, up to a month?
Original post in this thread
Maxpowermind · 10 points
I have found that Semax increase efficacy after a week or so of use and I usually only take it for a week or so anyway, during extremely demanding periods at work. I was wondering though if there any issues with taking Semax for up to a month without a break?
What they were answering
Debonaire_Death · 2 points
It gave me nasty problems with digestion when I used it for a month, and they didn't go right away when I stopped: if anything, they got worse for about a week before tapering off the next week.
There are definitely plenty of things we don't know about the drug, and some we are just finding out. For instance, I was talking about it with MYASD and he told me he only recently discovered that the SEMAX metabolite with the C-terminus complexes with copper in the brain, but because NASEMAXA amidates the C-terminus, this doesn't happen with NASEMAXA, which I didn't experience any appetite problems with at all after multiple months of cycling: my problem may have just been as simple as copper deficiency.
Many corticotropics have been shown to lower prostaglandins, as well, which are crucial for digestion, so I'm thinking that is also an option if I already had low prostaglandins (I was supplementing EFAs, though, so it shouldn't have been a problem). There are a lot of prostaglandin-lowering drugs (like the infamous nefiracetam) that will cause toxicity in animals with low prostaglandin levels, like dogs.
In my experience, it also lowers cortisol. I went to an endocrinologist to be tested for testosterone deficiency, and I was surprised to find out my cortisol was extremely low. Even with the R. rosea I was using, I wouldn't expect it to have such an extreme effect on my cortisol…
u/MisterYouAreSoDumb · Ceretropic
The copper complexing is confirmed in studies. The comments about the amidate not doing it are my own speculation, based on some assumptions. I just wanted to throw that out there, so people don't think that is a fact yet.